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doi: 10.2337/dc12-2006 77 RosenstockJRaccahDKornyiLMaffeiLBokaGMiossecPet al

The structure enables a comparison of the only two inactive peptide-free class B GPCR structures and increases our structural understanding of their activation pathways, which may be helpful in the design of novel ligands, thereby enabling new avenues for drug discovery on therapeutically important class B GPCRs

Data availability All data from this study are presented in the published article and the supplementary material

Degradation was slower than for hGLP-1 but clearly measurable, with less than 50% uncleaved pGLP-1 and eGLP-1 remaining after 11 hours of incubation (Table 1)

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