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Notably, aging-related AE1 protein conformational changes result in the appearance of a senescent-specific antigen recognized by autologous antibodies [75]

As our understanding of sleep biology evolves, DSIP serves as a reminder that promising findings require careful replication and rigorous clinical testing before they can be translated into patient care

It's not about limiting discovery

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We next asked whether reactive oxygen species (ROS) or subsequent NRF2 induction caused by GSH depletion could impact SLC25A39 levels