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Similarly, the phase 3 TRIUMPH-3 trial is recruiting patients struggling with overweight or obesity and who also have a history of cardiovascular disease

There is extensive enterohepatic circulation of vitamin B12, and then B12 is transported from the liver, via the bile duct, to the duodenum

However, it was discontinued as monotherapy for MASH after phase III trials failed to demonstrate sustained antifibrotic efficacy (179)

What we care about most, though, are interventional studies, where people are randomized to B12 so we can see what happens

Choosing your injection day matters too

(Eds.), Fundamentals of glycosylation (pp