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1 Introduction Polycystic ovary syndrome (PCOS) represents one of the most complex endocrine-metabolic disorders affecting women of reproductive age, characterized by a collection of reproductive, metabolic, and psychological manifestations ( Beyond the classic triad of hyperandrogenism (HA), ovulatory dysfunction, and polycystic ovarian morphology, PCOS extends into domains of insulin resistance, dyslipidemia, chronic inflammation, and heightened oxidative stress (OS) ( Conventional therapeutic strategies, though effective in symptom control, remain largely palliative, targeting isolated components of this multifactorial syndrome ( Thus, this review critically examines the triadic potential of these agents, not as standalone supplements but as a synergistic bioactive cocktail targeting the redox-endocrine axis

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Peeters TL, Muls E, Janssens J, Urbain JL, Bex M, Van Cutsem E, et al

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In immortalised human airway epithelial cell lines (including bronchial epithelial cells) and human alveolar epitheliallike cells, GLP-1 receptor agonists reduced epithelial stress and inflammatory signalling, including downregulation of epithelial-derived cytokines, including IL-33 and thymic stromal lymphopoietin (TSLP), both of which are implicated in epithelialmesenchymal crosstalk and fibroblast recruitment in fibrotic lung disease [66,67,68]

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