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NICE guidance specifies eligibility criteria including BMI thresholds (typically BMI 35 kg/m with weight-related comorbidities, or 30 kg/m with type 2 diabetes), use within specialist weight management services, and treatment duration limits

Together, these findings suggest that Semas ability to engage central appetite-regulating networksparticularly in the hypothalamus, brainstem, and reward centersmakes it a valuable compound for ongoing research into obesity, energy regulation, and neuroendocrine control of eating behavior

Mitri A, Castellano I (2023) Targeting gamma-glutamyl transpeptidase: A pleiotropic enzyme involved in glutathione metabolism and in the control of redox homeostasis

Holly Lofton, a doctor who specializes in obesity medicine at NYU Langone Health in New York

Theoretically, additive blood-glucose-lowering could occur, particularly in patients already on insulin or sulfonylureas

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