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Cagrilintide combined with semaglutide (CagriSema) for treatment of type 2 diabetes In a recent small phase 2 trial (n=92), 3 groups of patients with type 2 diabetes were randomized to receive cagrilintide co-administered with semaglutide (the authors called this combination CagriSema), cagrilintide or semaglutide, both in doses escalated to 2.4 mg once weekly (table 1) [10]

Regulatory and commercial factors rather than safety concerns explain this limitation

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While early findings have generated considerable scientific interest, much of the current evidence remains limited to laboratory and preclinical research

Descriptive analysis of suicidal and self-injurious adverse events among GLP-1RA users The clinical characteristics of GLP-1RA-associated suicide/self-injury are presented in Table 3