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Finan B, Yang B, Ottaway N, et al

GLP-1 receptor agonistsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)commonly affect bowel movements, though responses vary widely among patients

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Further research is needed to validate these findings in larger and more representative populations (e.g., evaluating real-life early PD populations using different symptomatic therapy patterns) and to explore alternative strategies for minimizing the confounding effects of symptomatic treatment adjustments

Inoue, T

However, after GLP-1RAs treatment, the joint structural damage was significantly alleviated and osteophyte formation was reduced (Fig