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Additional contributors may include a longer duration of obesity, older age, lower adherence to exercise, and possible behavioral factors in the T2DM population [46]

Management strategies for gastrointestinal effects focus on dietary modifications and gradual dose escalation

Risk factors associated with NAION can include diabetes, hypertension, sleep apnea, vascular disease, and other conditions affecting blood circulation and optic nerve health

With recent FDA enforcement against misleading direct-to-consumer prescription drug advertising, telehealth and DTC platforms that advertise GLP-1 products will likely need more careful legal / regulatory oversight of their ad claims, especially around benefit claims and safety disclosures

But even then, the injection site makes a difference

Your brain cells create orexin in the hypothalamus