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Signs and symptoms of vitamin B12 deficiency can include fatigue, pale skin, headaches, shortness of breath, fast heartbeat, gastrointestinal issues, mouth inflammation, paresthesias (abnormal sensations), decreased cognitive ability, depression, muscle weakness, imbalance and incoordination, vision problems, and erectile dysfunction

This in turn can produce toxic metabolites responsible for inhibiting CPS1

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~ AlphaMD As people age, their natural production of growth hormone declines, leading to a variety of symptoms, including reduced energy, slower metabolism, and decreased muscle mass

Breast Cancer 18 (1), e7e13