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Testing shows the product is 99.6% pure, with an assay result of 99.8%, meaning the material closely matches what it is supposed to be

however, to ensure tolerability in our subjects, a conservative approach was selected to ensure safety by starting at a low dose and titrating up

doi: 10.1007/s12031-020-01735-0 34 ChenB

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The 3R allele for this variant is associated with a 24 fold increase in expression of the TYMS enzyme, as a result of the effect of this variant on the translation efficiency of TYMS