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In one study, participants regained two-thirds of their previous weight loss within the year after stopping the medication

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In traditional clinical trials, a "responder" is someone who loses at least 5% of their body weight within the first three to six months

GLP-1 receptor agonists should be considered when patients experience significant weight regain with BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m, lifestyle modifications have been insufficient, no anatomical complications require surgical revision, and patients are willing to engage in long-term pharmacotherapy

Inspect the Vial and Stopper Check the physical integrity of the container