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Future research should adhere to the highest standards of preclinical and translational study design, including rigorous blinding, randomization, and power analysis, to enhance the validity and reproducibility of the results

ERK1/2 can phosphorylate GRK2 on Ser670, inhibiting kinase translocation and catalytic activity towards receptor membrane substrates (34), which may help to maintain the above process

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During the transition period, serum concentrations of TNF- tended to be greater in cows with lameness than in healthy animals 13

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