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e , The distances between catalytic residues Sec46 and Trp136 were recorded every 4.8 ps throughout MD simulations of GPX4 WT (PDB: 6HN3), GPX4 K48A , GPX4 K48L , GPX4 K48E , GPX4 K48Q , and GPX4 K48R

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The Master Antioxidant at Work Glutathione stands apart from other antioxidants through its simple and versatile structure

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Conversely, ferroptosis inhibitors significantly attenuate 6-OHDA-induced neuronal damage ( /GPX4 signaling axis in the prefrontal cortex of AD mice, upregulates ferritin light chain (FTL) and -site amyloid precursor protein cleaving enzyme 1 (BACE1), downregulates 4-hydroxynonenal (4-HNE), inhibits ferroptosis and lipid peroxidation, and ameliorates cognitive deficits (Li et al., 2024a)

The most common type of thyroid cancer is papillary thyroid carcinoma (PTC) 1,3