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Estrogen Exposure and Adipose-Driven Hormonal Modulation Because adipose tissue produces estrogen via aromatase, reductions in visceral fat can lower peripheral estrogen levels in some individuals

Mast cells produce interferon- (IFN) and IL-6 and appear to promote lesion development (90)

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Adaptive changes or doses of chemicals that induce adaptive changes usually do not result in illness or death of rodents

Patients with type 2 diabetes or metabolic syndrome may experience somewhat attenuated weight loss compared to metabolically healthy individuals