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The medication works through multiple complementary pathways to improve glycemic control and promote weight loss

Encouragement of healthy lifestyle changes: The use of this medication often motivates individuals to adopt long-term healthy habits and improve their metabolic health

It is essential to monitor for adverse events such as hypoglycemic episodes and blood pressure changes when using semaglutide, particularly in individuals with cardiovascular disease or risk factors related to heart attack and stroke

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doi: 10.1016/j.cmet.2024.07.023 Summary Keywords glucagon, glucagon resistance, -cell dysfunction, hyperglucagonemia, metabolic diseases Citation Lee SH, Park HY, Yun JH and Do EK (2025) Glucagon in metabolic disease: a mini-review of emerging multi-organ roles beyond glycemic control