The Phase 3 TRIUMPH-1 results released in May 2026 told a similar story: the common side effects were nausea, diarrhoea, constipation, vomiting, an altered skin sensation called dysesthesia, and urinary and respiratory infections
In my experience, tirzepatide patients hit plateau less frequently and later in their treatment course than semaglutide patients
This is when meal planning becomes important
In the STEP-1 trial, 1,961 patients were followed for 68 weeks and underwent randomization to semaglutide or placebo plus lifestyle intervention resulting in14.9% weight loss in the semaglutide group versus 2.5% in the placebo group [33]
Diabetes Care 37 , 19381943 (2014)
High-protein foods first at every meal, protein-forward snacks when you can tolerate them, and potentially protein shakes in formats that are easy on a nauseous stomach