Pharmacological activation of GPR68 with MS48107 or the clinically approved benzodiazepine Lorazepam robustly reversed ferroptosis by enhancing Akt phosphorylation and Nrf2 nuclear translocation
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When MCUs rapidly mediate calcium ions into the mitochondria, they also simultaneously mediate a large amount of iron into the mitochondrial matrix (Zhang et al., 2019), which can cause iron homeostasis disorder
doi: 10.1002/oby.21718
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