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Antioxidants can inhibit the expression of tumor suppressor proteins p53, a highly mutated transcription factor in cancer, and phosphatase and tensin homolog (PTEN), p21, and p27 (Singh et al

227,228 Immunomodulation HGF-overexpressing MSCs promote the differentiation of mature DCs (mDCs) into tolerogenic dendritic cells (DCregs) via direct cellcell contact, thus reducing ALI through the HGF/Akt pathway and the Notch pathway

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Keywords: Diabetes mellitus, Diabetes complications, Glucagon-like peptide 1 receptor agonists, Sodium-glucose cotransporter 2 inhibitors Key Summary Points Introduction Individuals with type 2 diabetes (T2D) face a heightened risk of cardiovascular and cerebrovascular (CV) events, alongside increased mortality