(PDF) Auerbach, R.P, Pagliaccio, D., Pizzagalli, D.A
GLP-1 exerts its effects through several key mechanisms: Glucose-dependent insulin secretion : GLP-1 stimulates pancreatic beta cells to release insulin, but only when blood glucose levels are elevated, reducing the risk of hypoglycaemia Glucagon suppression : It inhibits the release of glucagon from pancreatic alpha cells, thereby reducing hepatic glucose production Delayed gastric emptying : GLP-1 slows the rate at which food leaves the stomach, leading to more gradual glucose absorption and increased satiety Appetite regulation : Acting on brain centres, GLP-1 promotes feelings of fullness and reduces food intake Prescription GLP-1 receptor agonists (such as semaglutide, dulaglutide, and liraglutide) are synthetic analogues designed to mimic and enhance these natural effects
However, Semaglutide provides better flexibility for weight loss, whereas Ozempic is mainly targeted at diabetes management
Ebbing M, Bnaa KH, Nygrd O, et al
In fact, the outcomes from SURMOUNT approach the levels of weight reduction historically only seen with bariatric surgery
Enjoy a radiant, even tone