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They are generally well-tolerated and can provide faster, more effective results compared to oral supplements

However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue

When you reach the age of 65, you are much more likely to suffer from medical conditions, like atrophic gastritis, that reduce the ability to produce stomach acid

None of that makes them useless

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Most side effects are mild and transient