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Targeting the Trem2-APOE pathway can restore the homeostatic signature of microglia in ALS and AD mouse models, potentially preventing neuronal loss and promote tolerogenic T-cell response (Krasemann et al., 2017)

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Some 46% of participants who wore a nicotine patch and took exenatide stopped smoking, compared to 27% who only wore the patch, according to a 2021 study

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Indeed, the excitatory transmissions has been shown to be mediated by MAPK pathways [68]