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Ultrasonics Sonochemistry, 94, 106342

NAD + facilitates cellular energy metabolism NAD + /NADH as hydride-donating coenzyme for metabolism Acting as a coenzyme, NAD + plays pivotal roles in energy metabolism pathways including glycolysis, the TCA cycle, OXPHOS, FAO and alcohol (ethanol) metabolism

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Moreover, mice with neutrophil-specific Gpx4 haploinsufficiency develop lupus phenotype and inhibition of neutrophil ferroptosis significantly mitigates disease development in lupus-prone mice

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This connection underscores the need for integrated pharmacovigilance that considers both patient safety and environmental consequences