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CBS News' Dr
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PERK has been identified as a potential receptor for TMAO [147], suggesting its role in mediating TMAO signaling as endoplasmic reticulum (ER) stress, which activates the unfolded protein response (UPR)
Additionally, probiotics enhance the glucose-lowering/hypoglycemic effects of metformin by facilitating butyrate production, reflected by reductions in fasting blood glucose, insulin resistance, and fibronectin levels [148]
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