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4.3 The vicious cycle of metabolic deficits and immune activation Mitochondrial dysfunction may result in overproduction of ROS and the release of mtDNA, both of which serve as DAMPs, activating the NLRP3 inflammasome in both peripheral and central immune systems, thereby promoting the release of pro-inflammatory cytokines, such as IL-1 and IL-18 (168170)

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If you are in that category, the "non-conventional attractive side", or, in Marvin's terms, a sub five out of 10, Leander says he "can understand why it pushes you into an incel corner" - though he does not himself condone that