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The main outcome was hospitalization for heart failure and other outcomes were MACE outcomes (cardiovascular mortality, myocardial infarction, stroke, and all-cause mortality), metabolic outcomes (changes in HbA 1 c, weight, fasting plasma glucose (FPG)), and safety outcomes (severe adverse events, nausea, diarrhea, severe hypoglycemia, urinary tract infection, adverse events-related discontinuation)