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Goyal,Yogita O.Agrawal Food Hydrocolloids for Health 2 (2022) 100064 Guoyao Wu,Yun-Zhong Fang,Sheng Yang,Joanne R
S., Dorairaj S
While genetic association studies for common variants in the GDNF gene have been underpowered for tinnitus, plasma biomarker studies have identified GDNF among top circulating proteins associated with constant tinnitus, though these associations did not survive strict multiple testing corrections (Amanat et al., 2021
However: Longer-term safety data (5+ years) is still being collected Individual risk factors vary significantly Regular medical monitoring essential for ongoing safety assessment Some individuals develop side effects requiring discontinuation Long-term cardiovascular benefits observed in some trials (SELECT trial with semaglutide) Healthcare providers should regularly reassess whether continued treatment remains appropriate for individual circumstances based on ongoing benefits, risks, and patient preferences
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