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Due to the existence of the conjugated system of C = C bonds and carbonyl groups, 4-HNE can provide partial positive charge to the carbon at position three and become efficient electrophiles, allowing it to react with essential biological molecules, including proteins and DNA (107109)

Specific targeting of deubiquitylating enzymes or E3 ubiquitin ligase enzymes that are involved in well-characterized disease processes will enable the development of specific new treatment options in renal disease

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