Semaglutide and retatrutide both cause nausea, constipation, and potential pancreatitis risk
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Consider increased clinical or laboratory monitoring for medications that have a narrow therapeutic index or that require clinical monitoring Use in Specific Populations Pregnancy: May cause fetal harm
When these efforts are driven by real-world data, causal inference study design and analysis create greater confidence in the implementation and evaluation of insights

Contact your GP, specialist, or clinical trial team promptly if you experience: A spreading rash , hives (urticaria), or widespread skin redness that develops after starting treatment Swelling of the face, lips, tongue, or throat , which may indicate angioedema a potentially serious allergic reaction requiring urgent assessment Difficulty breathing or swallowing alongside skin changes call 999 immediately , as this could indicate anaphylaxis Signs of infection at an injection site , including increasing warmth, pus, significant swelling, or fever Persistent or worsening skin symptoms that do not improve with basic self-care measures after one to two weeks Unexplained bruising or bleeding beyond what would be expected from a subcutaneous injection If you are unsure whether your symptoms require urgent attention, NHS 111 can provide guidance
Whether youre new to GLP-1s or have been taking it for a while, its important to know how to use it