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Furthermore, the KDIGO 2024 guidelines cover combination therapy from the perspective of SGLT2is being first-line therapy, and long-acting GLP-1 RAs being an add-on in adults with CKD and T2D who have not achieved individualised glycaemic targets despite use of metformin and SGLT2is, or who are unable to use those medications [2]

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GLP-1 medications help reduce appetite and improve metabolic health when prescribed appropriately

Severe gastrointestinal side effects leading to dehydration can worsen kidney function

But both rest on a foundation of pivotal, replicated human trials that GHK-Cu simply does not have for this indication