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Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

Mol Oncol (2007) 1:288302

Particularly the safety issues

Weight loss difficulties can be caused by a number of different conditions

It activates GLP-1R (class B GPCR) to stimulate Gs-cAMP-PKA signaling in pancreatic beta cells for glucose-dependent insulin secretion, suppress appetite through hypothalamic GLP-1R activation, and slow gastric emptying via vagal pathways

2 But intuition and evidence are not the same thing, and the leap from amylin slows gastric emptying to a long-acting, continuously present amylin analog slows gastric emptying week after week hides a genuinely open scientific problem