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New York, Raven Press, p 427
doi: 10.1038/nchembio.2079 38 WuZGengYLuXShiYWuGZhangMet al
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Diseases with an autoimmune component damage particular cells mitochondrion
In one melanoma study, mice exposed to higher NAC doses experienced greater metastatic activity than those given lower doses, suggesting the effect may be dose-dependent in certain experimental settings.42 Researchers have not established whether these findings apply to humans, but starting with a moderate dose offers a more conservative approach while still aligning with a large portion of the clinical literature