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Gregor MF, Hotamisligil GS

Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1

By simultaneously activating these receptors, it lowers blood glucose, enhances insulin secretion and sensitivity, reduces appetite, and increases energy expenditure, resulting in pronounced weight loss and improved metabolic health 1,3