While it is generally considered safe, it is essential to consult with a healthcare provider before starting any new supplementation regimen
Specific deletion of igf-1 in the osteocyte using dentin matrix acidic phosphoprotein 1 (DMP-1) promoter driven Cre recombinase highlights the role of IGF-1 in regulating bone turnover during developmental bone growth as demonstrated by the reduced serum levels of the bone formation marker, procollagen type I N-terminal propeptide (PINP) and the bone resorption marker, c-telopeptide (CTx) and decreases in osteoclast surface and osteoclast numbers
doi: 10.1016/j.jpeds.2012.05.057 76 KalaraniIBVeerabathiranR
Administering a GH secretagogue into this milieu amplifies an already-elevated GH signal without guaranteeing proportional IGF-1 gain, making standard dosing assumptions unreliable
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