In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E (2020) DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25
Key Takeaways Loose skin is a structural issue: Significant weight loss stretches the physical matrix of the skin, which no cream can shrink back down
USA 103 , 1302213027 (2006)
Researchers and clinicians using it do so based on extrapolation from animal data and accumulating clinical experience rather than proven efficacy in humans
Hair remains in this phase for two to six years