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However, the results of clinical trials suggest that the characteristics of the cardiorenal protective effects achieved by these drugs differ slightly, and consensus for their use and evidence for their optimal use and combined benefits are still lacking

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Dry and pruritic skin is a common clinical manifestation of SS, with vasculitis being the second most common cutaneous manifestation, and histological examination usually confirms the diagnosis of leukocytoclastic vasculitis (LCV) [284]

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