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choline - alone or in combination with other methyl donors (B12, folate) ameliorates neurological impairment, and is an important constituent of phosphatidylcholine which is a major component of all membranes

[1] Other manifestations of B12 deficiency include glossitis (sore, red tongue), mouth ulcers, visual disturbances, and in severe cases, psychiatric symptoms such as depression, psychosis, or dementia-like presentations

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Retatrutide [1] is a unique triple receptor agonist that activates GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

Watkins, et al