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While the detectable glutarylation following ML226 treatment suggested that ABHD11 may be involved in regulating this modification, the glutaryl antibody was raised against glutaryl-lysine, making it unlikely that it could reliably detect lipoyl-glutarylation species

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The mechanism involves an increase in GLUT4 transporter expression, improving glucose uptake

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Saffron Saffron is a carotenoid-rich spice derived from the Crocus sativus flower, long used in both cooking and traditional medicine

The evidence remains primarily preclinical and anecdotal at this stage