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Reactive Oxygen Species (ROS) Attenuation Studies indicate that MT-1mediated cAMP elevation enhances antioxidant defense mechanisms in melanocytes, reducing UV-induced ROS accumulation and oxidative DNA damage through upregulation of superoxide dismutase and catalase activity (Abdel-Malek et al., Endocrine Reviews, 2010)
Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016
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To view a copy of this licence, visit About this article Cite this article Cassiano, L.M.G., de Paula, J.J., Rosa, D.V
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