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Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases

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Primary clinical outcomes The VAS was used to assess the severity of low back and leg pain in patients before and on days 1, 3, and 7, 1 month, 3 months, and 6 months after the operation

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