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As for ketogenic diet, a study in eight hospitalized patients with PWS (age 918 years) showed that a low-carbohydrate high-fat diet (15% carbohydrate, 65% fat, and 20% protein) increases glucagon-like peptide-1 (GLP-1) and reduces ghrelin/GLP-1 ratio, possibly limiting food intake and improving glycemic control as compared to a low-fat high-carbohydrate diet (65% carbohydrate, 15% fat, and 20% protein) [86]

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): A double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

Martin-Timon I, Sevillano-Collantes C, Segura-Galindo A, Del Canizo-Gomez FJ

KatiniosGCasado-BedmarMWalterSAVicarioMGonzalez-CastroAMBednarskaOet al