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Several groups have investigated in vivo intestinal permeability in MAFLD: small intestinal permeability by lactulose/mannitol (134140) or lactulose/rhamnose (141) and whole gut permeability by 51 Cr-EDTA (142) or sucralose (140)

At the same time, it is important to acknowledge the limitations of pivotal trials such as STEP and SELECT, whose generalisability is constrained by relatively short follow-up, notable dropout rates, and the predominance of Western cohorts

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[89] The potential increased risk of PPHN must be considered alongside the risks of untreated maternal depression, which can include increased rates of preeclampsia, preterm birth, and low birth weight