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When SIRT3 removes acetyl groups from isocitrate dehydrogenase 2 (IDH2), more NADPH gets made in mitochondria

Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

FIGURE 1 2.1 Metformin promotes follicular development and ovulation induction 2.1.1 Promoted autophagy in follicular granulosa cells Promoting follicular development and inducing ovulation are cornerstones in the management of infertility in PCOS

doi: 10.1111/j.1526-4610.2006.00454.x 92

Sadgrove NJ, Simmonds MSJ