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The remaining six mice were used as controls (NC)

Brazilian Journal of Surgery & Clinical Research , v

Gastrointestinal Overlap: A Primary Concern Both Wegovy and Orlistat are well-known for their gastrointestinal side effects, which could be a significant concern if taken together: Wegovy (semaglutide) typically causes side effects such as nausea, vomiting, diarrhea, constipation, and abdominal pain

The paper that named CJC-1295 Jett and colleagues in Endocrinology , 2005 identifies CJC-1295 explicitly as the tetrasubstituted form of hGRF(1-29) carrying an added N-3-maleimidopropionamide derivative of lysine at the C-terminus [1]

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doi: 10.3389/fimmu.2025.1730346 Received 22 October 2025 Revised 14 November 2025 Accepted 17 November 2025 Published 08 December 2025 Volume 16 - 2025 Edited by Moanaro Biswas, Indiana University, United States Reviewed by Narendra Chirmule, Indian Institute of Technology Bombay, India Andrea Di Ianni, Merck, Germany Updates Copyright 2025 Mattei, Roberts, Lelias, Miah, Howard, Weaver, Verthelyi, Pang, Edwards and De Groot