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There are three types of mUPD: i) isodisomy, caused by errors in meiosis II leading to non-disjunction of sister chromatids followed by trisomy rescue

Safe use in pregnant animals or animals intended for breeding has not been proven

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The importance of moderate hyperhomocysteinemia, and of other conventional risk factors such as age and sex, on the incidence of vascular pathologies are stressed in a recent case-controlled study conducted in nine European centers (Graham et al, 1997)