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A list of properties was evaluated, including: molecular weight, number of rotatable bonds, hydrogen bond acceptors, hydrogen bond donors, molar refractivity, topological polar surface area, logarithm of solubility (ESOL), average of the logarithm of the partition coefficient (Consensus), inhibition of the main cytochrome P450 (CYP450) isoforms (1A2, 2C9, 2C19, 2D6, and 3A4), gastrointestinal absorption, bloodbrain barrier permeability and inhibitor or substrate for Pglycoprotein

Any hormonal shifts are more likely attributable to weight loss itself rather than a direct pharmacological effect of Ozempic

Rosen P, Nawroth PP, King G, Moller W, Tritschler HJ, Packer L

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Litigation: Novo Nordisk sues in U.S