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Kim, J., Farchione, T., Potter, A., Chen, Q
BPC157 has been shown to enhance vascular endothelial growth factor (VEGF) expression, activate VEGFR2AkteNOS signaling, and stimulate endothelial cell proliferation and migration in rodent models of hind limb ischemia and tendon injury, resulting in accelerated blood flow recovery and capillary formation (12,13)
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For instance, P115 and GRASP65 trigger apoptosis via the ERK/p53/PUMA pathway or Fas-mediated signaling, respectively, whereas Bruce and GAAP decrease apoptosis via caspase-9, Smac and p53 inhibition, and Ca 2+ signaling downregulation [93]
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In their study, VCO administration significantly reduced serum creatinine, urea, and uric acid levels in a rat model of gentamicin-induced nephrotoxicity
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