For example, medications like Semaglutide and Tirzepatide, with their once-weekly dosing regimens, may have prolonged effects on gastric emptying of uncertain duration that persist beyond the medications active window, raising questions about the timing of preoperative fasting and the management of gastric residuals (Almandoz et al
Tricares approach mirrors many of the same tensions seen across commercial and government insurance programs: strong coverage when a diabetes diagnosis is present, significant restrictions when the goal is weight loss alone
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This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured
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