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Response: As previously discussed in this final rule with comment period, we believe the payer-specific negotiated charges would better reflect relative resources used because the rates that hospitals negotiate with MAOs capture the relative resource use to provide services to patients in order to maximize profits (or, in the case of not-for-profit hospitals, net income), subject to market constraints and conditions (supply and demand, community benefit requirements, etc.)

Always check local regulations and consult with healthcare providers before use

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I was not recommending a dose above, I only used 1 IU as an example

Beyond how much peptide is absorbed, the kinetics how fast it appears, peaks, and clears shape the practical experience of each route