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six males and six females) were anaesthetized with isoflurane and cardiac perfusion fixation was performed using a peristaltic pump, starting with NaCl for 4 min and followed by neutral buffered formalin (VWR International) for 8 min

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Pfizer's danuglipron, once considered the primary competitor, was discontinued in April 2025 after a case of potential drug-induced liver injury in a dose-optimization study, following the earlier termination of lotiglipron in 2023 for similar hepatic concerns