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Intracellular ROS are believed to be mainly produced by the mitochondria and NADPH oxidase (NOX) and can be associated with various physiological processes, such as proliferation, cell signaling, and oxygen homeostasis

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Hydrolysis of adenosine triphosphate (ATP) increases the intracellular ratio of AMP to ATP, leading to the activation of AMPK (169, 170)

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[DOI] [PubMed] [Google Scholar] 113.Liang W., Greven J., Qin K., Fragoulis A., Horst K., Blasius F., Wruck C., Pufe T., Kobbe P., Hildebrand F., et al